Article
Essential role of B-Raf in ERK activation during extraembryonic development.
Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 2006
Galabova-Kovacs Gergana, Matzen Dana, Piazzolla Daniela, Meissl Katrin, Plyushch Tatiana, Chen Adele P, Silva Alcino, Baccarini Manuela
Abstract excerpt
The kinases of the Raf family have been intensively studied as activators of the mitogen-activated protein kinase kinase/extra-cellular signal-regulated kinase (ERK) module in regulated and deregulated proliferation. Genetic evidence that Raf is required for ERK activation in vivo has been obtained in lower organisms, which express only one Raf kinase, but was hitherto lacking in mammals, which express more than...
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