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The AKT1-FOXO4 axis reciprocally regulates hemochorial placentation

6 Jan 2023

Abstract excerpt

Hemochorial placentation involves the differentiation of invasive trophoblast cells, specialized cells that possess the capacity to exit the placenta and invade into the uterus where they restructure the vasculature. Invasive trophoblast cells arise from a well-defined compartment within the placenta, referred to as the junctional zone in rat and the extravillous trophoblast cell column in human. In this study,...

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PMID: 36607602
DOI: 10.1242/dev.201095

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