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Article

Map2k1 and Map2k2 genes contribute to the normal development of syncytiotrophoblasts during placentation.

Development (Cambridge, England) - 1 Apr 2009

Nadeau Valérie, Guillemette Stéphanie, Bélanger Louis-François, Jacob Olivier, Roy Sophie, Charron Jean

Abstract excerpt

The mammalian genome contains two ERK/MAP kinase kinase genes, Map2k1 and Map2k2, which encode dual-specificity kinases responsible for ERK/MAP kinase activation. In the mouse, loss of Map2k1 function causes embryonic lethality, whereas Map2k2 mutants survive with a normal lifespan, suggesting that Map2k1 masks the phenotype due to the Map2k2 mutation. To uncover the specific function of MAP2K2 and the threshold...

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Identifiers

PMID: 19304888
DOI: 10.1242/dev.031872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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