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Article

An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development.

EMBO reports - 1 Oct 2003

Saba-El-Leil Marc K, Vella Francis D J, Vernay Bertrand, Voisin Laure, Chen Lan, Labrecque Nathalie, Ang Siew-Lan, Meloche Sylvain

Abstract excerpt

The closely related mitogen-activated protein kinase isoforms extracellular signal-regulated kinase 1 (ERK1) and ERK2 have been implicated in the control of cell proliferation, differentiation and survival. However, the specific in vivo functions of the two ERK isoforms remain to be analysed. Here, we show that disruption of the Erk2 locus leads to embryonic lethality early in mouse development after the...

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Source

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Identifiers

PMID: 14502223
DOI: 10.1038/sj.embor.embor939
PMCID: PMC1326397

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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