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Article

Tpbpa-Cre-mediated deletion of TFAP2C leads to deregulation of Cdkn1a, Akt1 and the ERK pathway, causing placental growth arrest.

Development (Cambridge, England) - 1 Mar 2016

Sharma Neha, Kubaczka Caroline, Kaiser Stephanie, Nettersheim Daniel, Mughal Sadaf S, Riesenberg Stefanie, Hölzel Michael, Winterhager Elke, Schorle Hubert

Abstract excerpt

Loss of TFAP2C in mouse leads to developmental defects in the extra-embryonic compartment with lethality at embryonic day (E)7.5. To investigate the requirement of TFAP2C in later placental development, deletion of TFAP2C was induced throughout extra-embryonic ectoderm at E6.5, leading to severe placental abnormalities caused by reduced trophoblast population and resulting in embryonic retardation by E8.5....

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Identifiers

PMID: 26811378
DOI: 10.1242/dev.128553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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