Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional redundancy of the kinases MEK1 and MEK2: Rescue of the Mek1 mutant phenotype by Mek2 knock-in reveals a protein threshold effect.

Science signaling - 26 Jan 2016

Aoidi Rifdat, Maltais Annie, Charron Jean

Abstract excerpt

The mammalian genome contains two mitogen-activated protein kinase (MAPK) kinase (MEK)-encoding genes, Mek1 and Mek2. MEKs phosphorylate and activate the two extracellular signal-regulated kinase (ERK) isoforms ERK1 and ERK2. Mek1(-/-) embryos die due to placental defects, whereas Mek2(-/-) mice survive with a normal life span and fertility, suggesting that MEK1 has functions not shared by MEK2. However, most...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crosses, Genetic
Share to Epitopes
Share to Gene Knock-In Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MAP Kinase Kinase 1

Share to MAP Kinase Kinase 2

Share to Microscopy, Fluorescence

Share to Placenta

Share to Pregnancy, Animal

Source

Identifiers

PMID: 26814233
DOI: 10.1126/scisignal.aad5658

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional redundancy of the kinases MEK1 and MEK2: Rescue of the Mek1 mutant phenotype by Mek2 knock-in reveals a protein threshold effect.PMID 26814233Read ↗

Fine-tuning of MEK signaling is pivotal for limiting B and T cell activation.Semantic proximity Read ↗

Functional Redundancy of ERK1 and ERK2 MAP Kinases during DevelopmentSemantic proximity Read ↗

MEK genomics in development and disease.Semantic proximity Read ↗

Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction.Semantic proximity Read ↗

Essential role of the ERK/MAPK pathway in blood-placental barrier formation.Semantic proximity Read ↗

Molecular mechanisms underlying cellular effects of human MEK1 mutations.Semantic proximity Read ↗

Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis.Semantic proximity Read ↗

Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway.Semantic proximity Read ↗

Functions of MAP kinases: insights from gene-targeting studies.Semantic proximity Read ↗

MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells.Semantic proximity Read ↗

Genome-wide expression profiling of placentas in the p57Kip2 model of pre-eclampsia.Semantic proximity Read ↗

Crucial requirement of ERK/MAPK signaling in respiratory tract development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.