Article
E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells.
Nature - 17 Dec 2009
Chong Jean-Leon, Wenzel Pamela L, Sáenz-Robles M Teresa, Nair Vivek, Ferrey Antoney, Hagan John P, Gomez Yorman M, Sharma Nidhi, Chen Hui-Zi, Ouseph Madhu, Wang Shu-Huei, Trikha Prashant, Culp Brian, Mezache Louise, Winton Douglas J, Sansom Owen J, Chen Danian, Bremner Rod, Cantalupo Paul G, Robinson Michael L, Pipas James M, Leone Gustavo
Abstract excerpt
In the established model of mammalian cell cycle control, the retinoblastoma protein (Rb) functions to restrict cells from entering S phase by binding and sequestering E2f activators (E2f1, E2f2 and E2f3), which are invariably portrayed as the ultimate effectors of a transcriptional program that...
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