Article
Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 May 2002
Saavedra Harold I, Wu Lizhao, de Bruin Alain, Timmers Cynthia, Rosol Thomas J, Weinstein Michael, Robinson Michael L, Leone Gustavo
Abstract excerpt
The Rb/E2F pathway plays a critical role in the control ofcellular proliferation. Here, we report that E2F1, E2F2, and E2F3 make major individual contributions toward the in vivo phenotypic consequences of Rb deficiency. In the developing lens of Rb(-/-) embryos, loss of E2F1, E2F2, or E2F3 reduces the unscheduled proliferation of fiber cells, with the loss of E2F3 having the most pronounced effect. In...
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