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Loss of<i>p53</i>Induces Changes in the Behavior of Subventricular Zone Cells: Implication for the Genesis of Glial Tumors

25 Jan 2006

Abstract excerpt

The role of multipotential progenitors and neural stem cells in the adult subventricular zone (SVZ) as cell-of-origin of glioblastoma has been suggested by studies on human tumors and transgenic mice. However, it is still unknown whether glial tumors are generated by all of the heterogeneous SVZ cell types or only by specific subpopulations of cells. It has been proposed that transformation could result from lack...

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PMID: 16436596
DOI: 10.1523/jneurosci.3970-05.2006

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