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Article

Filamin A Regulates Neural Progenitor Proliferation and Cortical Size through Wee1-Dependent Cdk1 Phosphorylation

30 May 2012

Abstract excerpt

Cytoskeleton-associated proteins play key roles not only in regulating cell morphology and migration but also in proliferation. Mutations in the cytoskeleton-associated gene filamin A (FlnA) cause the human disorder periventricular heterotopia (PH). PH is a disorder of neural stem cell development that is characterized by disruption of progenitors along the ventricular epithelium and subsequent formation of...

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PMID: 22649246
DOI: 10.1523/jneurosci.0894-12.2012

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Filamin A Regulates Neural Progenitor Proliferation and Cortical Size through Wee1-Dependent Cdk1 PhosphorylationPMID 22649246Read ↗

Filamin A in focus: unravelling the multifaceted roles of filamin A in neurodevelopment and neurological disordersSemantic proximity Read ↗

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Periventricular Heterotopia: Shuttling of Proteins through Vesicles and Actin in Cortical Development and DiseaseSemantic proximity Read ↗

Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia.Semantic proximity Read ↗

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