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Article

Smad4 and Trim33/Tif1γ redundantly regulate neural stem cells in the developing cortex.

Cerebral cortex (New York, N.Y. : 1991) - 1 Nov 2014

Falk Sven, Joosten Esméé, Kaartinen Vesa, Sommer Lukas

Abstract excerpt

During central nervous system (CNS) development, proliferation and differentiation of neural stem cells (NSCs) have to be regulated in a spatio-temporal fashion. Here, we report different branches of the transforming growth factor β (TGFβ) signaling pathway to be required for the brain area-specific control of NSCs. In the midbrain, canonical TGFβ signaling via Smad4 regulates the balance between proliferation...

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PMID: 23765158
DOI: 10.1093/cercor/bht149

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