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Article

The finger subdomain of yeast telomerase cooperates with Pif1p to limit telomere elongation.

Nature structural & molecular biology - 1 Aug 2006

Eugster Anne, Lanzuolo Chiara, Bonneton Manon, Luciano Pierre, Pollice Alessandra, Pulitzer John F, Stegberg Emma, Berthiau Anne-Sophie, Förstemann Klaus, Corda Yves, Lingner Joachim, Géli Vincent, Gilson Eric

Abstract excerpt

Telomere synthesis depends on telomerase, which contains an RNA subunit linked to a specialized reverse transcriptase subunit and several associated proteins. Here we report the characterization of four mutations in the yeast reverse transcriptase subunit Est2p that cause an overelongation of telomeres and an increase in the association of Est1p with telomeres during S phase. These 'up-mutations' are clustered in...

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PMID: 16878131
DOI: 10.1038/nsmb1126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The finger subdomain of yeast telomerase cooperates with Pif1p to limit telomere elongation.PMID 16878131Read ↗

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