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Article

The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA.

Molecular and cellular biology - 1 Mar 2000

Zhou J, Hidaka K, Futcher B

Abstract excerpt

Est1 is a component of yeast telomerase, and est1 mutants have senescence and telomere loss phenotypes. The exact function of Est1 is not known, and it is not homologous to components of other telomerases. We previously showed that Est1 protein coimmunoprecipitates with Tlc1 (the telomerase RNA) as well as with telomerase activity. Est1 has homology to Ebs1, an uncharacterized yeast open reading frame product,...

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Identifiers

PMID: 10688642
DOI: 10.1128/MCB.20.6.1947-1955.2000
PMCID: PMC110812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA.PMID 10688642Read ↗

Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes.Semantic proximity Read ↗

The interaction between the yeast telomerase RNA and the Est1 protein requires three structural elements.Semantic proximity Read ↗

A second essential function of the Est1-binding arm of yeast telomerase RNA.Semantic proximity Read ↗

Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction.Semantic proximity Read ↗

Est1 protects telomeres and inhibits subtelomeric y'-element recombination.Semantic proximity Read ↗

A Human Homolog of Yeast Est1 Associates with Telomerase and Uncaps Chromosome Ends When OverexpressedSemantic proximity Read ↗

A yeast telomerase complex containing the Est1 recruitment protein is assembled early in the cell cycle.Semantic proximity Read ↗

Est1p as a cell cycle-regulated activator of telomere-bound telomerase.Semantic proximity Read ↗

The anaphase promoting complex contributes to the degradation of the S. cerevisiae telomerase recruitment subunit Est1p.Semantic proximity Read ↗

The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein.Semantic proximity Read ↗

The telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro.Semantic proximity Read ↗

Stimulation of yeast telomerase activity by the ever shorter telomere 3 (Est3) subunit is dependent on direct interaction with the catalytic protein Est2.Semantic proximity Read ↗

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