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Article

A mutation in the catalytic subunit of yeast telomerase alters primer-template alignment while promoting processivity and protein-DNA binding.

Journal of cell science - 15 Dec 2011

Bairley Robin C B, Guillaume Gina, Vega Leticia R, Friedman Katherine L

Abstract excerpt

Telomerase is a ribonucleoprotein complex that is required for maintenance of linear chromosome ends (telomeres). In yeast, the Est2 protein reverse transcribes a short template region of the TLC1 RNA using the chromosome terminus to prime replication. Yeast telomeres contain heterogeneous G(1-3)T sequences that arise from incomplete reverse transcription of the TLC1 template and alignment of the DNA primer at...

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Identifiers

PMID: 22193961
DOI: 10.1242/jcs.090761
PMCID: PMC4074303

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A mutation in the catalytic subunit of yeast telomerase alters primer-template alignment while promoting processivity and protein-DNA binding.PMID 22193961Read ↗

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