Article
Est1p as a cell cycle-regulated activator of telomere-bound telomerase.
Science (New York, N.Y.) - 9 Aug 2002
Taggart Andrew K P, Teng Shu-Chun, Zakian Virginia A
Abstract excerpt
In Saccharomyces cerevisiae, the telomerase components Est2p, TLC1 RNA, Est1p, and Est3p are thought to form a complex that acts late during chromosome replication (S phase) upon recruitment by Cdc13p, a telomeric DNA binding protein. Consistent with this model, we show that Est1p, Est2p, and Cdc13p are telomere-associated at this time. However, Est2p, but not Est1p, also binds telomeres before late S phase. The...
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