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Article

Stimulation of yeast telomerase activity by the ever shorter telomere 3 (Est3) subunit is dependent on direct interaction with the catalytic protein Est2.

The Journal of biological chemistry - 29 Jul 2011

Talley Jennell M, DeZwaan Diane C, Maness Leslie D, Freeman Brian C, Friedman Katherine L

Abstract excerpt

Telomerase is a multisubunit enzyme that maintains genome stability through its role in telomere replication. Although the Est3 protein is long recognized as an essential telomerase component, how it associates with and functions in the telomerase complex has remained enigmatic. Here we provide the first evidence of a direct interaction between Saccharomyces cerevisiae Est3p and the catalytic protein subunit...

Topics

Mutation
Protein Binding
Protein Structure, Tertiary
Recombinant Proteins
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Telomerase

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 21659533
DOI: 10.1074/jbc.M111.228635
PMCID: PMC3143607

Genes

TERT
TPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Stimulation of yeast telomerase activity by the ever shorter telomere 3 (Est3) subunit is dependent on direct interaction with the catalytic protein Est2.PMID 21659533Read ↗

Telomerase regulatory subunit Est3 in two Candida species physically interacts with the TEN domain of TERT and telomeric DNA.Semantic proximity Read ↗

Saccharomyces cerevisiae Est3p dimerizes in vitro and dimerization contributes to efficient telomere replication in vivo.Semantic proximity Read ↗

The canonical RPA complex interacts with Est3 to regulate yeast telomerase activitySemantic proximity Read ↗

Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction.Semantic proximity Read ↗

A proposed OB-fold with a protein-interaction surface in Candida albicans telomerase protein Est3.Semantic proximity Read ↗

A mutation in the catalytic subunit of yeast telomerase alters primer-template alignment while promoting processivity and protein-DNA binding.Semantic proximity Read ↗

A second essential function of the Est1-binding arm of yeast telomerase RNA.Semantic proximity Read ↗

The interaction between the yeast telomerase RNA and the Est1 protein requires three structural elements.Semantic proximity Read ↗

Est1p as a cell cycle-regulated activator of telomere-bound telomerase.Semantic proximity Read ↗

The telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro.Semantic proximity Read ↗

The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitmentSemantic proximity Read ↗

The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA.Semantic proximity Read ↗

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