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Article

A second essential function of the Est1-binding arm of yeast telomerase RNA.

RNA (New York, N.Y.) - 1 May 2015

Lebo Kevin J, Niederer Rachel O, Zappulla David C

Abstract excerpt

The enzymatic ribonucleoprotein telomerase maintains telomeres in many eukaryotes, including humans, and plays a central role in aging and cancer. Saccharomyces cerevisiae telomerase RNA, TLC1, is a flexible scaffold that tethers telomerase holoenzyme protein subunits to the complex. Here we test the hypothesis that a lengthy conserved region of the Est1-binding TLC1 arm contributes more than simply Est1-binding...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25737580
DOI: 10.1261/rna.049379.114
PMCID: PMC4408794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A second essential function of the Est1-binding arm of yeast telomerase RNA.PMID 25737580Read ↗

Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction.Semantic proximity Read ↗

The interaction between the yeast telomerase RNA and the Est1 protein requires three structural elements.Semantic proximity Read ↗

A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase proteinSemantic proximity Read ↗

The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA.Semantic proximity Read ↗

A mutation in the catalytic subunit of yeast telomerase alters primer-template alignment while promoting processivity and protein-DNA binding.Semantic proximity Read ↗

The telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro.Semantic proximity Read ↗

Stimulation of yeast telomerase activity by the ever shorter telomere 3 (Est3) subunit is dependent on direct interaction with the catalytic protein Est2.Semantic proximity Read ↗

The finger subdomain of yeast telomerase cooperates with Pif1p to limit telomere elongation.Semantic proximity Read ↗

Est1 and Cdc13 as comediators of telomerase access.Semantic proximity Read ↗

A new telomerase RNA element that is critical for telomere elongation.Semantic proximity Read ↗

A yeast telomerase complex containing the Est1 recruitment protein is assembled early in the cell cycle.Semantic proximity Read ↗

Est1 protects telomeres and inhibits subtelomeric y'-element recombination.Semantic proximity Read ↗

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