Article
A second essential function of the Est1-binding arm of yeast telomerase RNA.
RNA (New York, N.Y.) - 1 May 2015
Lebo Kevin J, Niederer Rachel O, Zappulla David C
Abstract excerpt
The enzymatic ribonucleoprotein telomerase maintains telomeres in many eukaryotes, including humans, and plays a central role in aging and cancer. Saccharomyces cerevisiae telomerase RNA, TLC1, is a flexible scaffold that tethers telomerase holoenzyme protein subunits to the complex. Here we test the hypothesis that a lengthy conserved region of the Est1-binding TLC1 arm contributes more than simply Est1-binding...
Topics
- Base Sequence
- Conserved Sequence
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Organisms, Genetically Modified
- Protein Binding
- RNA
- Ribonucleoproteins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Telomerase
- Telomere
- Telomere Homeostasis