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Article

Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes.

Genetics - 1 Dec 1996

Lendvay T S, Morris D K, Sah J, Balasubramanian B, Lundblad V

Abstract excerpt

The primary determinant for telomere replication is the enzyme telomerase, responsible for elongating the G-rich strand of the telomere. The only component of this enzyme that has been identified in Saccharomyces cerevisiae is the TLC1 gene, encoding the telomerase RNA subunit. However, a yeast s...

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Amino Acid Sequence
Cloning, Molecular
DNA-Binding Proteins
Fungal Proteins
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

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Identifiers

PMID: 8978029
DOI: 10.1093/genetics/144.4.1399
PMCID: PMC1207693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-8978029-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes.PMID 8978029Read ↗

The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA.Semantic proximity Read ↗

Est1p as a cell cycle-regulated activator of telomere-bound telomerase.Semantic proximity Read ↗

Using Separation-of-Function Mutagenesis To Define the Full Spectrum of Activities Performed by the Est1 Telomerase Subunit in Vivo.Semantic proximity Read ↗

Stimulation of yeast telomerase activity by the ever shorter telomere 3 (Est3) subunit is dependent on direct interaction with the catalytic protein Est2.Semantic proximity Read ↗

A genome-wide screen for essential yeast genes that affect telomere length maintenance.Semantic proximity Read ↗

Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants.Semantic proximity Read ↗

The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein.Semantic proximity Read ↗

Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction.Semantic proximity Read ↗

Saccharomyces cerevisiae Est3p dimerizes in vitro and dimerization contributes to efficient telomere replication in vivo.Semantic proximity Read ↗

SGS1 is required for telomere elongation in the absence of telomerase.Semantic proximity Read ↗

The canonical RPA complex interacts with Est3 to regulate yeast telomerase activitySemantic proximity Read ↗

The finger subdomain of yeast telomerase cooperates with Pif1p to limit telomere elongation.Semantic proximity Read ↗

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