Article
DEFB1 gene polymorphisms and tuberculosis in a Northeastern Brazilian population.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] - 1 Jan 2000
Celerino da Silva Ronaldo, da Cruz Heidi Lacerda Alves, Brandão Lucas André Cavalcanti, Guimarães Rafael Lima, Montenegro Lilian Maria Lapa, Schindler Haiana Charifker, Segat Ludovica, Crovella Sergio
Abstract excerpt
β-Defensin-1, an antimicrobial peptide encoded by the DEFB1 gene, is known to play an important role in lung mucosal immunity. In our association study we analyzed three DEFB1 functional polymorphisms -52G>A (rs1799946), -44C>G (rs1800972) and -20G>A (rs11362) in 92 tuberculosis patients and 286 healthy controls, both from Northeast Brazil: no association was found between the studied DEFB1 polymorphisms and the...
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