Article
Functional single-nucleotide polymorphisms in the DEFB1 gene are associated with systemic lupus erythematosus in Southern Brazilians.
Lupus - 1 May 2012
Sandrin-Garcia P, Brandão L A C, Guimarães R L, Pancoto J A T, Donadi E A, Lima-Filho J L de, Segat L, Crovella S
Abstract excerpt
Systemic lupus erythematosus (SLE) is an autoimmune disease that results in inflammation and tissue damage. The etiology of SLE remains unknown, but recent studies have shown that the innate immune system may have a role in SLE pathogenesis through the secretion of small cationic peptides named defensins. The aim of the study was to determine the possible involvement in SLE of three functional single nucleotide...
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