Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation.

Molecular and cellular biology - 1 Mar 2009

Huang Xingxu, Andreu-Vieyra Claudia V, Wang Meizhi, Cooney Austin J, Matzuk Martin M, Zhang Pumin

Abstract excerpt

Separase is a critical protease that catalyzes the cleavage of sister chromatid cohesins to allow the separation of sister chromatids in the anaphase. Its activity must be inhibited prior to the onset of the anaphase. Two inhibitory mechanisms exist in vertebrates that block the protease activity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blastocyst
Share to Cell Cycle Proteins
Share to Chromatids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Segregation

Share to Chromosomes, Mammalian

Share to Endopeptidases

Share to Oocytes

Share to Phosphorylation

Source

Open in PubMed Open full text

Identifiers

PMID: 19124608
DOI: 10.1128/MCB.01778-08
PMCID: PMC2648233

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19124608-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation.PMID 19124608Read ↗

Cyclin-B1-mediated inhibition of excess separase is required for timely chromosome disjunction.Semantic proximity Read ↗

A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes.Semantic proximity Read ↗

Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II.Semantic proximity Read ↗

Age-Dependent Susceptibility of Chromosome Cohesion to Premature Separase Activation in Mouse Oocytes1Semantic proximity Read ↗

Overexpression of SETβ, a protein localizing to centromeres, causes precocious separation of chromatids during the first meiosis of mouse oocyteSemantic proximity Read ↗

Age‐dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase BSemantic proximity Read ↗

Mutual inhibition of separase and Cdk1 by two-step complex formation.Semantic proximity Read ↗

Spindle assembly checkpoint regulates mitotic cell cycle progression during preimplantation embryo development.Semantic proximity Read ↗

Protein phosphatase 2A and separase form a complex regulated by separase autocleavage.Semantic proximity Read ↗

Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis ISemantic proximity Read ↗

Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1γ-WAPL Axis in the Mouse.Semantic proximity Read ↗

Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.