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Article

Evidence for abasic site sugar phosphate-mediated cytotoxicity in alkylating agent treated Saccharomyces cerevisiae.

PloS one - 1 Jan 2012

Heacock Michelle, Poltoratsky Vladimir, Prasad Rajendra, Wilson Samuel H

Abstract excerpt

To better understand alkylating agent-induced cytotoxicity and the base lesion DNA repair process in Saccharomyces cerevisiae, we replaced the RAD27(FEN1) open reading frame (ORF) with the ORF of the bifunctional human repair enzyme DNA polymerase (Pol) β. The aim was to probe the effect of removal of the incised abasic site 5'-sugar phosphate group (i.e., 5'-deoxyribose phosphate or 5'-dRP) in protection against...

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Share to Antineoplastic Agents, Alkylating
Share to DNA Polymerase beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flap Endonucleases

Share to Immunoblotting

Share to Methyl Methanesulfonate

Share to Microbial Viability

Share to Phosphorus-Oxygen Lyases

Share to Transformation, Genetic

Source

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Identifiers

PMID: 23144716
DOI: 10.1371/journal.pone.0047945
PMCID: PMC3483300

Genes

FEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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