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Article

Antifolate response in replication arrest mutants of Saccharomyces cerevisiae.

Anticancer research - 1 May 2013

Dornfeld Ken

Abstract excerpt

AIM: Thymidine deprivation is a common cancer treatment. This study examines the role of replication arrest and uracil DNA repair in response to thymidine deprivation. MATERIALS AND METHODS: Strains of S. cerevisiae deficient in various replication and DNA repair functions were tested for sensitivity to thymidine deprivation induced by the antifolate aminopterin. Cell survival and DNA content were assayed...

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PMID: 23645753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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