Article
Altered drug sensitivities to anticancer agents in radiation-sensitive DNA repair deficient yeast mutants.
Anticancer research - 1 Jan 2000
Abe H, Wada M, Kohno K, Kuwano M
Abstract excerpt
We studied whether cellular sensitivity to anticancer agents was correlated with a repair deficiency in three yeast epistasis groups of radiation sensitive mutants. All these mutants were hypersensitive to cisplatin and mitomycin C. By contrast, both rad51 and rad52 mutants deficient in double-strand breaks repair were hypersensitive to adriamycin and bleomycin, but the rad1 and rad10 mutants deficient in...
Topics
- Antineoplastic Agents
- Bleomycin
- Cisplatin
- DNA
- DNA Damage
- DNA Repair
- DNA, Fungal
- Doxorubicin
- Drug Resistance
- Drug Screening Assays, Antitumor
- Mitomycin
- Mutation