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Article

Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses.

The Journal of biological chemistry - 10 Oct 2003

Sobol Robert W, Kartalou Maria, Almeida Karen H, Joyce Donna F, Engelward Bevin P, Horton Julie K, Prasad Rajendra, Samson Leona D, Wilson Samuel H

Abstract excerpt

DNA alkylation damage is primarily repaired by the base excision repair (BER) machinery in mammalian cells. In repair of the N-alkylated purine base lesion, for example, alkyl adenine DNA glycosylase (Aag) recognizes and removes the base, and DNA polymerase beta (beta-pol) contributes the gap tailoring and DNA synthesis steps. It is the loss of beta-pol-mediated 5'-deoxyribose phosphate removal that renders mouse...

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Share to Alkylating Agents
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Methyl Methanesulfonate

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Share to Recombination, Genetic

Source

Identifiers

PMID: 12882965
DOI: 10.1074/jbc.M306592200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses.PMID 12882965Read ↗

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Protection against methylation-induced cytotoxicity by DNA polymerase beta-dependent long patch base excision repair.Semantic proximity Read ↗

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Alkylation Base Damage Is Converted into Repairable Double-Strand Breaks and Complex Intermediates in G2 Cells Lacking AP EndonucleaseSemantic proximity Read ↗

Base excision repair and nucleotide excision repair contribute to the removal of N-methylpurines from active genes.Semantic proximity Read ↗

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ATM safeguards DNA replication at endogenous base lesionsSemantic proximity Read ↗

Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivitySemantic proximity Read ↗

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