Nucleotide excision repair deficiency causes elevated levels of chromosome gain in Saccharomyces cerevisiae.

Abstract excerpt

Aneuploidy is the most frequent aberration observed in tumor cells, and underlies many debilitating and cancer-prone congenital disorders. Aneuploidy most often arises as a consequence of chromosomal non-disjunction, however, little is known about the genetic and epigenetic factors that affect the chromosomal segregation process. As many cancer-prone syndromes are associated with defects in DNA repair pathways we...

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