Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AP endonuclease deficiency results in extreme sensitivity to thymidine deprivation.

Nucleic acids research - 1 Jan 2005

Dornfeld Ken, Johnson Monika

Abstract excerpt

Thymidine depletion is toxic to virtually all actively growing cells. The fundamental mechanism responsible for thymidineless death remains unknown. One event thought to be critical in causing the toxicity of thymidine depletion is a sharp rise in the ratio of dUTP to dTTP and subsequent incorporation of dUTP into DNA. Maneuvers to alter dUTP levels appear to alter the toxicity of thymidine depletion. However,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair
Share to DNA Repair Enzymes
Share to Endodeoxyribonucleases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Folic Acid Antagonists

Share to Mutation

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Share to Thymidine

Source

Open in PubMed Open full text

Identifiers

PMID: 16314323
DOI: 10.1093/nar/gki975
PMCID: PMC1298931

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AP endonuclease deficiency results in extreme sensitivity to thymidine deprivation.PMID 16314323Read ↗

Antifolate response in replication arrest mutants of Saccharomyces cerevisiae.Semantic proximity Read ↗

Base excision repair of both uracil and oxidatively damaged bases contribute to thymidine deprivation-induced radiosensitization.Semantic proximity Read ↗

Involvement of two endonuclease III homologs in the base excision repair pathway for the processing of DNA alkylation damage in Saccharomyces cerevisiae.Semantic proximity Read ↗

Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation.Semantic proximity Read ↗

AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe.Semantic proximity Read ↗

Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae.Semantic proximity Read ↗

Repair of DNA strand breaks by the overlapping functions of lesion-specific and non-lesion-specific DNA 3' phosphatases.Semantic proximity Read ↗

Endogenous DNA abasic sites cause cell death in the absence of Apn1, Apn2 and Rad1/Rad10 in Saccharomyces cerevisiae.Semantic proximity Read ↗

Interplay of DNA repair pathways controls methylation damage toxicity in Saccharomyces cerevisiae.Semantic proximity Read ↗

DNA damage-processing pathways involved in the eukaryotic cellular response to anticancer DNA cross-linking drugs.Semantic proximity Read ↗

DNA mismatch repair mutants do not increase N-methyl-N'-nitro-N-nitrosoguanidine tolerance in O6-methylguanine DNA methyltransferase-deficient yeast cells.Semantic proximity Read ↗

dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.