Article
Yeast base excision repair: interconnections and networks.
Progress in nucleic acid research and molecular biology - 1 Jan 2001
Doetsch P W, Morey N J, Swanson R L, Jinks-Robertson S
Abstract excerpt
The removal of oxidative base damage from the genome of Saccharomyces cerevisiae is thought to occur primarily via the base excision repair (BER) pathway in a process initiated by several DNA N-glycosylase/AP lyases. We have found that yeast strains containing simultaneous multiple disruptions of BER genes are not hypersensitive to killing by oxidizing agents, but exhibit a spontaneous hyperrecombinogenic...
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