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Article

Inactivation of RAD52 and HDF1 DNA repair genes leads to premature chronological aging and cellular instability.

Journal of biosciences - 1 Jun 2017

Mercado-Saenz Silvia, Lopez-Diaz Beatriz, Sendra-Portero Francisco, Martinez-Morillo Manuel, Ruiz-Gomez Miguel J

Abstract excerpt

The present study aims to investigate the role of radiation sensitive 52 (RAD52) and high-affinity DNA binding factor 1 (HDF1) DNA repair genes on the life span of budding yeasts during chronological aging. Wild type (wt) and rad52, hdf1, and rad52 hdf1 mutant Saccharomyces cerevisiae strains were used. Chronological aging and survival assays were studied by clonogenic assay and drop test. DNA damage was analyzed...

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Source

Identifiers

PMID: 28569246
DOI: 10.1007/s12038-017-9684-7

Genes

RAD52

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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