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Article

Low frequency of CHEK2 mutations in familial pancreatic cancer.

Familial cancer - 1 Jan 2006

Bartsch Detlef K, Krysewski Kristina, Sina-Frey Mercedes, Fendrich Volker, Rieder Harald, Langer Peter, Kress Ralf, Schneider Margarete, Hahn Stephan A, Slater Emily P

Abstract excerpt

Familial pancreatic cancer (FPC) is a rare tumour syndrome and its underlying major gene defect is still unknown. Recently, CHEK2 has been identified as multi-organ cancer susceptibility gene associated with a predisposition to breast, prostate and colon cancer. Since these cancers also are associated with some FPC families, we have analysed 35 index patients of German FPC families for CHEK2 mutations. The CHEK2...

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Source

Identifiers

PMID: 16858628
DOI: 10.1007/s10689-006-7850-4

Genes

CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Low frequency of CHEK2 mutations in familial pancreatic cancer.PMID 16858628Read ↗

The Prevalence of Founder Mutations among Individuals from Families with Familial Pancreatic Cancer Syndrome.Semantic proximity Read ↗

CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify the risk of sporadic pancreatic cancer.Semantic proximity Read ↗

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Limited relevance of the CHEK2 gene in hereditary breast cancer.Semantic proximity Read ↗

The risk of gastric cancer in carriers of CHEK2 mutations.Semantic proximity Read ↗

CDKN2A is the main susceptibility gene in Italian pancreatic cancer families.Semantic proximity Read ↗

CHEK2 1100delC is a susceptibility allele for HNPCC-related colorectal cancer.Semantic proximity Read ↗

Low frequency of CHEK2 1100delC allele in Australian multiple-case breast cancer families: functional analysis in heterozygous individuals.Semantic proximity Read ↗

CHEK2 c.1100delC allele is rarely identified in Greek breast cancer cases.Semantic proximity Read ↗

CHEK2 1100delC is prevalent in Swedish early onset familial breast cancer.Semantic proximity Read ↗

German populations with infrequent CHEK2*1100delC and minor associations with early-onset and familial breast cancer.Semantic proximity Read ↗

The breast cancer low-penetrance allele 1100delC in the CHEK2 gene is not present in Spanish familial breast cancer population.Semantic proximity Read ↗

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