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Article

CHEK2 1100delC is prevalent in Swedish early onset familial breast cancer.

BMC cancer - 17 Aug 2007

Margolin Sara, Eiberg Hans, Lindblom Annika, Bisgaard Marie Luise

Abstract excerpt

BACKGROUND: A truncating variant, 1100delC, in check point-kinase CHEK2, has been identified as a risk factor for familial and sporadic breast cancer. The prevalence in healthy non-breast cancer cases is low and varies between populations. METHODS: We analyzed the prevalence of CHEK2 1100delC in 763 breast cancer patients with a defined family history and 760 controls from the Stockholm region. The breast cancer...

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Identifiers

PMID: 17705858
DOI: 10.1186/1471-2407-7-163
PMCID: PMC1994956

Genes

CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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CHEK2 1100delC is prevalent in Swedish early onset familial breast cancer.PMID 17705858Read ↗

German populations with infrequent CHEK2*1100delC and minor associations with early-onset and familial breast cancer.Semantic proximity Read ↗

Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers.Semantic proximity Read ↗

CHEK2 1100delC variant and breast cancer risk in Caucasians: a meta-analysis based on 25 studies with 29,154 cases and 37,064 controls.Semantic proximity Read ↗

Frequency of CHEK2 mutations in a population based, case-control study of breast cancer in young women.Semantic proximity Read ↗

A search for modifying genetic factors in CHEK2:c.1100delC breast cancer patients.Semantic proximity Read ↗

CHEK2*1100delC homozygosity in the Netherlands--prevalence and risk of breast and lung cancer.Semantic proximity Read ↗

CHEK2 c.1100delC allele is rarely identified in Greek breast cancer cases.Semantic proximity Read ↗

Frequency of CHEK2*1100delC in New York breast cancer cases and controls.Semantic proximity Read ↗

CHEK2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10,860 breast cancer cases and 9,065 controls from 10 studies.Semantic proximity Read ↗

Limited relevance of the CHEK2 gene in hereditary breast cancer.Semantic proximity Read ↗

Tumour characteristics and prognosis of breast cancer patients carrying the germline CHEK2*1100delC variant.Semantic proximity Read ↗

CHEK2*1100delC is not an important high-risk gene in families with hereditary prostate cancer in southern Sweden.Semantic proximity Read ↗

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