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Article

CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify the risk of sporadic pancreatic cancer.

Cancer epidemiology - 1 Oct 2010

Mohelnikova-Duchonova Beatrice, Havranek Ondrej, Hlavata Ivona, Foretova Lenka, Kleibl Zdenek, Pohlreich Petr, Soucek Pavel

Abstract excerpt

Checkpoint kinase 2 gene (CHEK2) alterations increase risk of several cancer types. We analyzed selected CHEK2 alterations in 270 Czech pancreatic cancer patients and in 683 healthy controls. The pancreatic cancer risk was higher in individuals who inherited rare alterations in CHEK2 region involving forkhead-associated domain other than I157T (OR=5.14; 95% CI=0.94-28.23) but the observed association was...

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Source

Identifiers

PMID: 20643596
DOI: 10.1016/j.canep.2010.06.008

Genes

CHEK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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