Article
Limited relevance of the CHEK2 gene in hereditary breast cancer.
International journal of cancer - 20 Jun 2004
Dufault Michael R, Betz Beate, Wappenschmidt Barbara, Hofmann Wera, Bandick Katrin, Golla Astrid, Pietschmann Andrea, Nestle-Krämling Caroline, Rhiem Kerstin, Hüttner Christine, von Lindern Celia, Dall Peter, Kiechle Marion, Untch Michael, Jonat Walter, Meindl Alfons, Scherneck Siegfried, Niederacher Dieter, Schmutzler Rita K, Arnold Norbert
Abstract excerpt
To establish the importance of CHEK2 mutations for familial breast cancer incidence in the German population, we have screened all 14 of the coding exons in 516 families negative for mutations in both the BRCA1 and BRCA2 genes. We found 12 distinct variants in 30 unrelated patients (5.81%), including 5 that are novel and an additional 4 found for the first time in breast cancer. These aberrations were evaluated...
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