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Article

CDKN2A is the main susceptibility gene in Italian pancreatic cancer families.

Journal of medical genetics - 1 Mar 2012

Ghiorzo Paola, Fornarini Giuseppe, Sciallero Stefania, Battistuzzi Linda, Belli Fiorenza, Bernard Loris, Bonelli Luigina, Borgonovo Giacomo, Bruno William, De Cian Franco, Decensi Andrea, Filauro Marco, Faravelli Francesca, Gozza Alberto, Gargiulo Sara, Mariette Frederique, Nasti Sabina, Pastorino Lorenza, Queirolo Paola, Savarino Vincenzo, Varesco Liliana, Scarrà Giovanna Bianchi

Abstract excerpt

Background Most familial pancreatic cancer (FPC) remains unexplained. The identification of individuals with a high genetic risk of developing pancreatic adenocarcinoma (PC) is important to elucidate its biological basis and is critical to better define emerging strategies for the detection of early pancreatic neoplasms. Patients and methods A series of 225 consecutively enrolled patients with PC were tested for...

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Source

Identifiers

PMID: 22368299
DOI: 10.1136/jmedgenet-2011-100281

Genes

BRCA1
BRCA2
PALB2
PALLD

Variants

Provenance

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