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Article

The breast cancer low-penetrance allele 1100delC in the CHEK2 gene is not present in Spanish familial breast cancer population.

International journal of cancer - 1 Jan 2004

Osorio Ana, Rodríguez-López Raquel, Díez Orland, de la Hoya Miguel, Ignacio Martínez José, Vega Ana, Esteban-Cardeñosa Eva, Alonso Carmen, Caldés Trinidad, Benítez Javier

Abstract excerpt

Searching for low-penetrance genes involved in breast cancer susceptibility has been a field of interest in the last few years. Recently, the CHEK 2 gene, involved in DNA damage and replication checkpoints, has been pointed out as a good candidate; moreover, a specific variant in this gene,1100delC, has been found to increase breast cancer susceptibility among familial breast cancer cases not attributable to...

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Source

Identifiers

PMID: 14618615
DOI: 10.1002/ijc.11414

Genes

BRCA1
BRCA2
CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The breast cancer low-penetrance allele 1100delC in the CHEK2 gene is not present in Spanish familial breast cancer population.PMID 14618615Read ↗

The CHEK2 1100delC allele is not relevant for risk assessment in HNPCC and HBCC Spanish families.Semantic proximity Read ↗

Absence of the CHEK2 c.1100delC mutation in familial breast and ovarian cancer in Colombia: a case-control studySemantic proximity Read ↗

CHEK2 c.1100delC allele is rarely identified in Greek breast cancer cases.Semantic proximity Read ↗

CHEK2 1100DELC germline mutation: a frequency study in hereditary breast and colon cancer Brazilian families.Semantic proximity Read ↗

Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility.Semantic proximity Read ↗

Limited relevance of the CHEK2 gene in hereditary breast cancer.Semantic proximity Read ↗

CHEK2 c.1100delC mutation among non-BRCA1/2 Spanish hereditary breast cancer families.Semantic proximity Read ↗

CHEK2 1100delC variant and breast cancer risk in Caucasians: a meta-analysis based on 25 studies with 29,154 cases and 37,064 controls.Semantic proximity Read ↗

Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations.Semantic proximity Read ↗

Breast cancer low-penetrance allele 1100delC in the CHEK2 gene: not present in the Chinese familial breast cancer population.Semantic proximity Read ↗

CHEK2*1100delC homozygosity in the Netherlands--prevalence and risk of breast and lung cancer.Semantic proximity Read ↗

CHEK2 1100delC is prevalent in Swedish early onset familial breast cancer.Semantic proximity Read ↗

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