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Article

CHEK2 1100delC is a susceptibility allele for HNPCC-related colorectal cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2008

Wasielewski Marijke, Vasen Hans, Wijnen Juul, Hooning Maartje, Dooijes Dennis, Tops Carli, Klijn Jan G M, Meijers-Heijboer Hanne, Schutte Mieke

Abstract excerpt

PURPOSE: The pathogenic CHEK2 1100delC variant is firmly established as a breast cancer susceptibility allele. Dutch CHEK2 1100delC breast cancer families frequently also include colorectal cancer cases, and the variant is particularly prevalent among breast cancer families with hereditary breast and colorectal cancer. Yet, it is still unclear whether CHEK2 1100delC also confers a colorectal cancer risk...

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Identifiers

PMID: 18676774
DOI: 10.1158/1078-0432.CCR-08-0389

Genes

CHEK2
FAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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CHEK2 1100delC is a susceptibility allele for HNPCC-related colorectal cancer.PMID 18676774Read ↗

Colorectal cancer and the CHEK2 1100delC mutation.Semantic proximity Read ↗

CHEK2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10,860 breast cancer cases and 9,065 controls from 10 studies.Semantic proximity Read ↗

CHEK2 1100delC variant and breast cancer risk in Caucasians: a meta-analysis based on 25 studies with 29,154 cases and 37,064 controls.Semantic proximity Read ↗

A search for modifying genetic factors in CHEK2:c.1100delC breast cancer patients.Semantic proximity Read ↗

Increased risk of breast cancer associated with CHEK2*1100delC.Semantic proximity Read ↗

The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype.Semantic proximity Read ↗

CHEK2*1100delC homozygosity in the Netherlands--prevalence and risk of breast and lung cancer.Semantic proximity Read ↗

CHEK2 1100DELC germline mutation: a frequency study in hereditary breast and colon cancer Brazilian families.Semantic proximity Read ↗

Meta-analysis of CHEK2 1100delC variant and colorectal cancer susceptibility.Semantic proximity Read ↗

CHEK2*1100delC genotyping for clinical assessment of breast cancer risk: meta-analyses of 26,000 patient cases and 27,000 controls.Semantic proximity Read ↗

Cancer risks for other sites in addition to breast in CHEK2 c.1100delC families.Semantic proximity Read ↗

Cohort profile: a nationwide study in Dutch CHEK2 c.1100delC families using the infrastructure of the HEreditary Breast and Ovarian cancer study Netherlands - Hebon-CHEK2.Semantic proximity Read ↗

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