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Article

Regulation by SIRPα of dendritic cell homeostasis in lymphoid tissues.

Blood - 4 Nov 2010

Saito Yasuyuki, Iwamura Hiroko, Kaneko Tetsuya, Ohnishi Hiroshi, Murata Yoji, Okazawa Hideki, Kanazawa Yoshitake, Sato-Hashimoto Miho, Kobayashi Hisae, Oldenborg Per-Arne, Naito Makoto, Kaneko Yoriaki, Nojima Yoshihisa, Matozaki Takashi

Abstract excerpt

The molecular basis for regulation of dendritic cell (DC) development and homeostasis remains unclear. Signal regulatory protein α (SIRPα), an immunoglobulin superfamily protein that is predominantly expressed in DCs, mediates cell-cell signaling by interacting with CD47, another immunoglobulin superfamily protein. We now show that the number of CD11c(high) DCs (conventional DCs, or cDCs), in particular, that of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20682853
DOI: 10.1182/blood-2010-03-277244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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