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Article

An extracatalytic function of CD45 in B cells is mediated by CD22.

Proceedings of the National Academy of Sciences of the United States of America - 24 Nov 2015

Coughlin Sarah, Noviski Mark, Mueller James L, Chuwonpad Ammarina, Raschke William C, Weiss Arthur, Zikherman Julie

Abstract excerpt

The receptor-like tyrosine phosphatase CD45 regulates antigen receptor signaling by dephosphorylating the C-terminal inhibitory tyrosine of the src family kinases. However, despite its abundance, the function of the large, alternatively spliced extracellular domain of CD45 has remained elusive. We used normally spliced CD45 transgenes either incorporating a phosphatase-inactivating point mutation or lacking the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CSK Tyrosine-Protein Kinase

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Source

Open in PubMed Open full text

Identifiers

PMID: 26561584
DOI: 10.1073/pnas.1519925112
PMCID: PMC4664364

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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