Article

Priming of Myelin-Specific T Cells in the Absence of Dendritic Cells Results in Accelerated Development of Experimental Autoimmune Encephalomyelitis

2020-12-29

Abstract excerpt

Experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS), is predominantly mediated by pro-inflammatory CD4 + T cell responses to CNS antigens, including myelin proteolipid protein (PLP). Dendritic cells (DCs) are considered critical for inducing T cell responses against infectious agents, but the importance of DCs in priming self-reactive CD4+ T cells in autoimmune disease suc...

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Literature Corpus work: 61c4d3a5-5c13-559f-8d23-f0c998dcd259
DOI: 10.1101/2020.12.28.424609

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Priming of Myelin-Specific T Cells in the Absence of Dendritic Cells Results in Accelerated Development of Experimental Autoimmune EncephalomyelitisDOI 10.1101/2020.12.28.424609Read

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