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Article

Distinct genetic loci control development of benign and malignant skin tumours in mice.

Nature genetics - 1 Aug 1995

Nagase H, Bryson S, Cordell H, Kemp C J, Fee F, Balmain A

Abstract excerpt

Genetic susceptibility to chemically induced skin cancer in mice is controlled by multiple unlinked genetic loci. Mus spretus mice have dominant resistance genes which confer resistance to interspecific F1 hybrids with susceptible Mus musculus strains. We have mapped three major resistance loci using a combination of Mapmaker/QTL analysis and multiple regression analysis to mouse chromosomes 5 and 7. At least two...

Topics

Animals
Chromosome Mapping
Crosses, Genetic
Female
Genetic Predisposition to Disease
Male
Mice
Papilloma
Regression Analysis
Skin Neoplasms
Software

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7670492
DOI: 10.1038/ng0895-424

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7670492-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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