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Article

AIMP3 haploinsufficiency disrupts oncogene-induced p53 activation and genomic stability.

Cancer research - 15 Jul 2006

Park Bum-Joon, Oh Young Sun, Park Seung Yong, Choi So Jung, Rudolph Cornelia, Schlegelberger Brigitte, Kim Sunghoon

Abstract excerpt

AIMP3 (previously known as p18) was shown to up-regulate p53 in response to DNA damage. Here, we show that AIMP3 couples oncogenic stresses to p53 activation to prevent cell transformation. Growth factor- or Ras-dependent induction of p53 was blocked by single allelic loss of AIMP3 as well as by suppression of AIMP3. AIMP3 heterozygous cells became susceptible to cell transformation induced by oncogenes such as...

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Share to Cell Transformation, Neoplastic
Share to Cyclin-Dependent Kinase Inhibitor p18

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Mammalian

Share to Fibroblasts

Share to Genes, ras

Share to Genomic Instability

Share to RNA, Antisense

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 16849534
DOI: 10.1158/0008-5472.CAN-05-3740

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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