Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination.

doi:10.1038/sj.emboj.7600712

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Article

Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination.

The EMBO journal - 6 Jul 2005

Yan Chunhong, Lu Dan, Hai Tsonwin, Boyd Douglas D

Abstract excerpt

Activating transcription factor 3 (ATF3) is rapidly induced by diverse environmental insults including genotoxic stress. We report herein that its interaction with p53, enhanced by genotoxic stress, stabilizes the tumor suppressor thereby augmenting functions of the latter. Overexpression of ATF3 (but not a mutated ATF3 protein (Delta102-139) devoid of its p53-binding region) prevents p53 from MDM2-mediated...

Topics

Activating Transcription Factor 3
Active Transport, Cell Nucleus
Animals
Apoptosis
Cell Line
Cell Nucleus
Cell Transformation, Neoplastic
DNA Damage
Embryo, Mammalian
Fibroblasts
Genes, ras

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Mice

Mutagens

Mutation

Nuclear Proteins

Protein Binding

Protein Structure, Tertiary

Source

Open in PubMed Open full text

Identifiers

PMID: 15933712
DOI: 10.1038/sj.emboj.7600712
PMCID: PMC1173153

Genes

ATF3
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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