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Article

The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR.

Cell - 28 Jan 2005

Park Bum-Joon, Kang Jin Wook, Lee Sang Won, Choi So-Jung, Shin Young Kee, Ahn Young Ha, Choi Yun Hee, Choi Dongho, Lee Kwang Soo, Kim Sunghoon

Abstract excerpt

p18 was first identified as a factor associated with a macromolecular tRNA synthetase complex. Here we describe the mouse p18 loss-of-function phenotype and a role for p18 in the DNA damage response. Inactivation of both p18 alleles caused embryonic lethality, while heterozygous mice showed high susceptibility to spontaneous tumors. p18 was induced and translocated to the nucleus in response to DNA damage....

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Source

Identifiers

PMID: 15680327
DOI: 10.1016/j.cell.2004.11.054

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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