Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Survival of BRCA2-Deficient Cells Is Promoted by GIPC3, a Novel Genetic Interactor of BRCA2.

Genetics - 1 Dec 2017

Ding Xia, Philip Subha, Martin Betty K, Pang Yan, Burkett Sandra, Swing Deborah A, Pamala Chinmayi, Ritt Daniel A, Zhou Ming, Morrison Deborah K, Ji Xinhua, Sharan Shyam K

Abstract excerpt

BRCA2 loss-of-heterozygosity (LOH) is frequently observed in BRCA2-mutated tumors, but its biallelic loss causes embryonic lethality in mice and inhibits proliferation of normal somatic cells. Therefore, it remains unclear how loss of BRCA2 contributes to tumorigenesis. One possibility is that mutation in potential genetic interactors of BRCA2, such as TRP53, is required for cell survival/proliferation in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to BRCA2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinogenesis

Share to Carrier Proteins

Share to Gene Expression Regulation, Neoplastic

Share to Loss of Heterozygosity

Share to Mouse Embryonic Stem Cells

Share to Mutagenesis, Insertional

Source

Open in PubMed Open full text

Identifiers

PMID: 29021281
DOI: 10.1534/genetics.117.300357
PMCID: PMC5714451

Genes

BRCA2
GIPC3
APPL1
APPL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Survival of BRCA2-Deficient Cells Is Promoted by GIPC3, a Novel Genetic Interactor of BRCA2.PMID 29021281Read ↗

G6PC3 promotes genome maintenance and is a candidate mammary tumor suppressorSemantic proximity Read ↗

Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2.Semantic proximity Read ↗

<i>Palb2</i> synergizes with <i>Trp53</i> to suppress mammary tumor formation in a model of inherited breast cancerSemantic proximity Read ↗

Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay.Semantic proximity Read ↗

3p21.3 tumor suppressor cluster: prospects for translational applicationsSemantic proximity Read ↗

HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicitySemantic proximity Read ↗

Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds.Semantic proximity Read ↗

AIMP3 haploinsufficiency disrupts oncogene-induced p53 activation and genomic stability.Semantic proximity Read ↗

Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1.Semantic proximity Read ↗

The Rap1 guanine nucleotide exchange factor C3G is required for preservation of larval muscle integrity in Drosophila melanogaster.Semantic proximity Read ↗

brca2-mutant zebrafish exhibit context- and tissue-dependent alterations in cell phenotypes and response to injury.Semantic proximity Read ↗

The Caenorhabditis elegans ing-3 gene regulates ionizing radiation-induced germ-cell apoptosis in a p53-associated pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.