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Article

Downregulation of lamin A by tumor suppressor AIMP3/p18 leads to a progeroid phenotype in mice.

Aging cell - 1 Oct 2010

Oh Young Sun, Kim Dae Gyu, Kim Gyuyoup, Choi Eung-Chil, Kennedy Brian K, Suh Yousin, Park Bum Joon, Kim Sunghoon

Abstract excerpt

Although AIMP3/p18 is normally associated with the macromolecular tRNA synthetase complex, recent reports have revealed a new role of AIMP3 in tumor suppression. In this study, we generated a transgenic mouse that overexpresses AIMP3 and characterized the associated phenotype in vivo and in vitro. Surprisingly, the AIMP3 transgenic mouse exhibited a progeroid phenotype, and the cells that overexpressed AIMP3...

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Identifiers

PMID: 20726853
DOI: 10.1111/j.1474-9726.2010.00614.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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