Article
MK3 modulation affects BMI1-dependent and independent cell cycle check-points.
PloS one - 1 Jan 2015
Prickaerts Peggy, Niessen Hanneke E C, Dahlmans Vivian E H, Spaapen Frank, Salvaing Juliette, Vanhove Jolien, Geijselaers Claudia, Bartels Stefanie J J, Partouns Iris, Neumann Dietbert, Speel Ernst-Jan, Takihara Yoshihiro, Wouters Bradly G, Voncken Jan Willem
Abstract excerpt
Although the MK3 gene was originally found deleted in some cancers, it is highly expressed in others. The relevance of MK3 for oncogenesis is currently not clear. We recently reported that MK3 controls ERK activity via a negative feedback mechanism. This prompted us to investigate a potential role for MK3 in cell proliferation. We here show that overexpression of MK3 induces a proliferative arrest in normal...
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