Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fragments of ATM which have dominant-negative or complementing activity.

Molecular and cellular biology - 1 Apr 1997

Morgan S E, Lovly C, Pandita T K, Shiloh Y, Kastan M B

Abstract excerpt

The ATM protein has been implicated in pathways controlling cell cycle checkpoints, radiosensitivity, genetic instability, and aging. Expression of ATM fragments containing a leucine zipper motif in a human tumor cell line abrogated the S-phase checkpoint after ionizing irradiation and enhanced radiosensitivity and chromosomal breakage. These fragments did not abrogate irradiation-induced G1 or G2 checkpoints,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Complementary

Share to DNA Primers

Share to Genes, p53

Share to Genetic Complementation Test

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 9121450
DOI: 10.1128/MCB.17.4.2020
PMCID: PMC232049

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fragments of ATM which have dominant-negative or complementing activity.PMID 9121450Read ↗

The role of ATM in DNA damage responses and cancer.Semantic proximity Read ↗

Splitting the ATM: distinct repair and checkpoint defects in ataxia-telangiectasia.Semantic proximity Read ↗

Requirement of sequences outside the conserved kinase domain of fission yeast Rad3p for checkpoint control.Semantic proximity Read ↗

The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different speciesSemantic proximity Read ↗

A single ataxia telangiectasia gene with a product similar to PI-3 kinase.Semantic proximity Read ↗

ATM: the product of the gene mutated in ataxia-telangiectasia.Semantic proximity Read ↗

ATM&A Key Determinant of Multiple Cellular Responses to IrradiationSemantic proximity Read ↗

ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia.Semantic proximity Read ↗

ATM Kinase Dead: From Ataxia Telangiectasia Syndrome to CancerSemantic proximity Read ↗

Inhibition of ATM kinase activity does not phenocopy ATM protein disruptionSemantic proximity Read ↗

ATM Mutations in Cancer: Therapeutic Implications.Semantic proximity Read ↗

Molecular perspectives on cancer, the cell cycle and the inherited disorder ataxia-telangiectasia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.