Article
RET as a Diagnostic and Therapeutic Target in Sporadic and Hereditary Endocrine Tumors
18 Jul 2006
Abstract excerpt
The RET gene encodes a receptor tyrosine kinase that is expressed in neural crest-derived cell lineages. The RET receptor plays a crucial role in regulating cell proliferation, migration, differentiation, and survival through embryogenesis. Activating mutations in RET lead to the development of several inherited and noninherited diseases. Germline point mutations are found in the cancer syndromes multiple...
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