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Article

RET proto-oncogene mutations in multiple endocrine neoplasia type 2 and medullary thyroid carcinoma.

Bailliere's clinical endocrinology and metabolism - 1 Jul 1995

Cote G J, Wohllk N, Evans D, Goepfert H, Gagel R F

Abstract excerpt

The identification of RET proto-oncogene mutations in patients with MEN2 2 years ago was a watershed event in the management of this genetic cancer syndrome. The identification of a finite number of mutations that together causes more than 95% of hereditary and 15-25% of sporadic MTC has made it possible to develop simple and definitive tests to screen individuals at risk for this tumour syndrome. The impact of...

Topics

Carcinoma, Medullary
Drosophila Proteins
Genetic Testing
Humans
Multiple Endocrine Neoplasia Type 2a
Multiple Endocrine Neoplasia Type 2b
Mutation
Point Mutation
Proto-Oncogene Mas
Proto-Oncogene Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-ret

Receptor Protein-Tyrosine Kinases

Thyroid Neoplasms

Source

Identifiers

PMID: 7575334
DOI: 10.1016/s0950-351x(95)80638-5

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7575334-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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