Article
RET proto-oncogene mutations in multiple endocrine neoplasia type 2 and medullary thyroid carcinoma.
Bailliere's clinical endocrinology and metabolism - 1 Jul 1995
Cote G J, Wohllk N, Evans D, Goepfert H, Gagel R F
Abstract excerpt
The identification of RET proto-oncogene mutations in patients with MEN2 2 years ago was a watershed event in the management of this genetic cancer syndrome. The identification of a finite number of mutations that together causes more than 95% of hereditary and 15-25% of sporadic MTC has made it possible to develop simple and definitive tests to screen individuals at risk for this tumour syndrome. The impact of...
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