Article
RET and neuroendocrine tumors.
Pituitary - 1 Jan 2006
Murakumo Yoshiki, Jijiwa Mayumi, Asai Naoya, Ichihara Masatoshi, Takahashi Masahide
Abstract excerpt
The RET proto-oncogene encodes a receptor tyrosine kinase that is a main component of the signaling pathway activated by the glial cell line-derived neurotrophic factor family ligands. Gene targeting studies revealed that signaling through RET plays a crucial role in neuronal and renal organogenesis. It is well-known that germline mutations in RET lead to the human inherited diseases, multiple endocrine neoplasia...
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